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KMID : 0604519970230030097
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Journal of the Society of Cosmetic Scientists of Korea
1997 Volume.23 No. 3 p.97 ~ p.100
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In vitro cell recovery method as an alternative to hyman damaged skin recovery test
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An, Su-Sun
Nam, Ki-Taek/Park, Jong-Ho/Koh, Jae-Sook
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Abstract
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These days, the raw materials that have the cell recovering effect are used commonly in cosmetics. In this study, six materials were tested for the characteristics of recovering effect both in vivo and in vitro. Tested raw utaterials were Soypol, 3-APPA, Apple extract, Polygonatum japonicum extract, Scutellaria baicalensis extract, Aloe extract. Among these taterials, Soypol and 3-AP11A were synthesized and others were rttade by extraction at the Pacific R&D Center. Human foreann skin and cultured skin cells were damaged by sodium lauryl sulfate (SLS) and then raw materials were applied for open treaunent on SLS damaged hutman skin or cells.
The recovering effects of raw ntarerials in vivo were evaluated by measuring transepidennal water loss (TEWL), skin hydration and erythema and in vitro effects of proliferating cells were assessed by neutral red uptake assay. In the in vino study, only the evaluation by TEWL showed correlation with the visual score. Out of six materials, 3-APPA had the most positive effect in both in vitro and in vitb studies and the correlation was r = 0.8286 (p = 0.042).
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